Welcome to the ECHA website. 0000263639 00000 n Geneva, Switz. The authors did not utilise a consideration of historical control data in their conclusion. 0000117262 00000 n 0000263268 00000 n 0000231187 00000 n Register, Oxford University Press is a department of the University of Oxford. As glutathione stores were depleted, binding to proteins and cytotoxicity ensued. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Available at:http://www.inchem.org/documents/jecfa/jecmono/v56je09.pdf/. In female mice, the incidence of hepatocellular adenomas and carcinomas (combined) was statistically significant only at the high-dose; although a dose-response trend was seen, the incidences of adenomas or carcinomas alone were not statistically significant at either dose. Control efficiency of naled-intoxicated ME was found to be significantly lower in the field and resistant strains compared to the susceptible strain. 0000741238 00000 n This conclusion is consistent with that of the recent review of the toxicology of eugenol conducted by the European Food Safety Authority, which concluded that eugenol is devoid of carcinogenic activity (EFSA, 2009). ME non-responsiveness was found to be 1.7–1.9% in our lab-reared strains (both naled-resistant and susceptible) and 3.4–4.3% in field strains. In this study, mark-recapture experiments were used to analyze the effects of naled-intoxicated ME on field and naled-resistant fly strains. 0000011782 00000 n 0000099395 00000 n EFSA. You do not currently have access to this article. This article is also available for rental through DeepDyve. 0000116866 00000 n A lack of structural alerts for genotoxic and non-genotoxic carcinogenicity. A statistically significant increase in hepatocellular tumours in male mice at the low-dose level, but not at the mid- and high-dose level, indicating a lack of a dose-response relationship; 3. : World Health Organization (WHO); 2006a. 0000670899 00000 n Finally, the effects of fipronil-intoxicated ME were analyzed to determine whether control efficiency could be enhanced through the use of alternate pesticides. 0000120522 00000 n 0000183053 00000 n The authors did not utilise a consideration of historical control data in their conclusion. 0000015449 00000 n Methyl eugenol has been shown to be metabolised by allylic 1'-hydroxylation followed by sulphation leading to an unstable genotoxic metabolite. Moreover, the incidence of either tumour type alone at the high-dose level was not statistically significantly different from the control group. 0000183594 00000 n ��8W0�p:0� 0000119055 00000 n 0000125676 00000 n Hum Exp Toxicol 1998;17:193-205. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). 0000358013 00000 n Department of Entomology, National Taiwan University, No. �:�UH0�(:0l 0000099417 00000 n Conversely, restoration of glutathione by addition of N-acetylcysteine prevented the onset of cytotoxicity; 5. 0000118486 00000 n H��W]�d7���s�=�m�,�5I Oi�Ca�lv7a���W�,���������'^ޟ��o?O�p�p��Ib���7k4�?-��s>L��!-��9|;�z �Q��傡HT|�L�;�}� ��x�I! 0000279211 00000 n 0001083069 00000 n 0000775208 00000 n 0000265526 00000 n Consequently, methyl eugenol is not a valid analogue of eugenol. You could not be signed in. 0000448997 00000 n 0000543564 00000 n 0000126254 00000 n 0000118224 00000 n 0000115373 00000 n 0000116583 00000 n 0000375850 00000 n For full access to this pdf, sign in to an existing account, or purchase an annual subscription. 56). Finally, capture rates of naled-resistant flies increased when naled was replaced with fipronil in attractants, showing that use of pesticides with different modes of action could possibly increase control efficiency of intoxicated ME attractants. Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice. 0000003226 00000 n Mouse-specific carcinogens: An assessment of hazard and significance for validation of short- term carcinogenicity bioassays in transgenic mice. Eugenol and related hydroxyallylbenzne derivatives\. Chemical Listed Effective November 16, 2001 as Known to the State of California to Cause Cancer: Methyleugenol; Notice of Intent to List Chemical: Methyleugenol; Anthraquinone, AZT, Bromate ion and its water soluble salts, Bromoethane, Diuron, Fumonisn B1, Isoxaflutole, Methyl eugenol, Gemfibrozil, and Zileuton Under Consideration for Listing 0001008911 00000 n Available at:http://whqlibdoc.who.int/trs/WHO_TRS_934_eng.pdf. Po-Hung Chen, Wen-Jer Wu, Ju-Chun Hsu, Detection of Male Oriental Fruit Fly (Diptera: Tephritidae) Susceptibility to Naled- and Fipronil-Intoxicated Methyl Eugenol, Journal of Economic Entomology, Volume 112, Issue 1, February 2019, Pages 316–323, https://doi.org/10.1093/jee/toy278.
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